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13 results

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Page 1
The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis.
Xu D, Wang Z, Xia Y, Shao F, Xia W, Wei Y, Li X, Qian X, Lee JH, Du L, Zheng Y, Lv G, Leu JS, Wang H, Xing D, Liang T, Hung MC, Lu Z. Xu D, et al. Nature. 2020 Apr;580(7804):530-535. doi: 10.1038/s41586-020-2183-2. Epub 2020 Apr 8. Nature. 2020. PMID: 32322062
Phosphorylated PCK1 translocates to the endoplasmic reticulum, where it uses GTP as a phosphate donor to phosphorylate INSIG1 at Ser207 and INSIG2 at Ser151. This phosphorylation reduces the binding of sterols to INSIG1 and INSIG2 and disrupts the interaction betwee …
Phosphorylated PCK1 translocates to the endoplasmic reticulum, where it uses GTP as a phosphate donor to phosphorylate INSIG1 at Ser2 …
Prognostic Significance of HMGA1 Expression in Lung Cancer Based on Bioinformatics Analysis.
Saed L, Jeleń A, Mirowski M, Sałagacka-Kubiak A. Saed L, et al. Int J Mol Sci. 2022 Jun 22;23(13):6933. doi: 10.3390/ijms23136933. Int J Mol Sci. 2022. PMID: 35805937 Free PMC article.
The high HMGA1 expression level was connected with shorter overall and first progression survival time among lung adenocarcinoma patients, but not lung squamous cell carcinoma patients. HMGA1 could interact with proteins involved in cellular senescence and cell cycle contr …
The high HMGA1 expression level was connected with shorter overall and first progression survival time among lung adenocarcinoma pati …
Comprehensive Analysis of DNA Methylation and Prediction of Response to NeoadjuvantTherapy in Locally Advanced Rectal Cancer.
do Canto LM, Barros-Filho MC, Rainho CA, Marinho D, Kupper BEC, Begnami MDFS, Scapulatempo-Neto C, Havelund BM, Lindebjerg J, Marchi FA, Baumbach J, Aguiar S Jr, Rogatto SR. do Canto LM, et al. Cancers (Basel). 2020 Oct 22;12(11):3079. doi: 10.3390/cancers12113079. Cancers (Basel). 2020. PMID: 33105711 Free PMC article.
External validation was carried out with The Cancer Genome Atlas-Rectal Adenocarcinoma (TCGA-READ 99 cases). A classifier based on three-CpGs DM (linked to OBSL1, GPR1, and INSIG1 genes) was able to discriminate pCR from incomplete responders with high sensitivity a …
External validation was carried out with The Cancer Genome Atlas-Rectal Adenocarcinoma (TCGA-READ 99 cases). A classifier based on th …
Bicluster and pathway enrichment analysis related to tumor progression of hepatocellular carcinoma.
Wang SY, Feng LY, Meng ZQ. Wang SY, et al. Eur Rev Med Pharmacol Sci. 2015 Apr;19(7):1191-7. Eur Rev Med Pharmacol Sci. 2015. PMID: 25912578 Free article.
RESULTS: Our analysis indicated that several differentially expressed genes might play crucial roles in the progression of hepatocellular carcinoma, such as GADD45G, SPTBN1, CDC27, TPD52 and INSIG1. GADD45G and SPTBN1 not only contribute to tumor progression in hepatocellu …
RESULTS: Our analysis indicated that several differentially expressed genes might play crucial roles in the progression of hepatocellular ca …
Cell Free DNA of Tumor Origin Induces a 'Metastatic' Expression Profile in HT-29 Cancer Cell Line.
Fűri I, Kalmár A, Wichmann B, Spisák S, Schöller A, Barták B, Tulassay Z, Molnár B. Fűri I, et al. PLoS One. 2015 Jul 2;10(7):e0131699. doi: 10.1371/journal.pone.0131699. eCollection 2015. PLoS One. 2015. PMID: 26133168 Free PMC article.
AIMS: To evaluate and compare the potential autocrine and paracrine regulatory effect of normal and malignant epithelial cell-related DNA on TLR9 and STING mediated pathways in HT-29 human colorectal adenocarcinoma cells and normal fibroblasts. MATERIALS AND METHODS: DNA i …
AIMS: To evaluate and compare the potential autocrine and paracrine regulatory effect of normal and malignant epithelial cell-related DNA on …
Human evidence for the involvement of insulin-induced gene 1 in the regulation of plasma glucose concentration.
Krapivner S, Chernogubova E, Ericsson M, Ahlbeck-Glader C, Hamsten A, van 't Hooft FM. Krapivner S, et al. Diabetologia. 2007 Jan;50(1):94-102. doi: 10.1007/s00125-006-0479-x. Epub 2006 Nov 15. Diabetologia. 2007. PMID: 17106696
A significant (p = 0.02) reduction in expression of phosphoenolpyruvate carboxykinase (PCK2) was observed following siRNA inhibition of INSIG1 in human Huh7 hepatoma cells. CONCLUSIONS/INTERPRETATION: Population studies demonstrate that INSIG1 plays a role in glucos …
A significant (p = 0.02) reduction in expression of phosphoenolpyruvate carboxykinase (PCK2) was observed following siRNA inhibition of I …
Prostate cancer gene expression signature of patients with high body mass index.
Sharad S, Srivastava A, Ravulapalli S, Parker P, Chen Y, Li H, Petrovics G, Dobi A. Sharad S, et al. Prostate Cancer Prostatic Dis. 2011 Mar;14(1):22-9. doi: 10.1038/pcan.2010.44. Epub 2010 Nov 9. Prostate Cancer Prostatic Dis. 2011. PMID: 21060327 Free PMC article.
Knowledge-based analyses revealed an association of high BMI with altered levels of lipid metabolism and cholesterol homeostasis genes, such as stearoyl-CoA desaturase 1 (SCD1) and insulin-induced gene 1 (INSIG1), respectively, in prostate tumor cells. These genes were con …
Knowledge-based analyses revealed an association of high BMI with altered levels of lipid metabolism and cholesterol homeostasis genes, such …
13 results